Many digitally enabled art forms, especially those using interactive interfaces, operate in a different conceptual, aesthetic, and methodological framework from traditional plastic arts. They are dynamic, engaging multiple senses, and substituting objects with processes, and they can both shift and extend the nature of perceptual experiences. How can the potential of these new forms be understood? One approach is suggested by recent research on brain plasticity, which studies how the brain can be rapidly and radically changed through specific interactions with the environment, pointing the way to a form of neuroplastic arts that enables and exploits these changes.